WebJun 1, 2009 · The PDGRFA locus has become a gene of interest based on mutational activation in various myeloid neoplasms and the availability of targeted therapies (i.e., … WebApr 9, 2024 · Information about CHIC2, 4q12 Deletion (FIP1L1 and PDGFRA Fusion), FISH, Blood. Search our extensive database of medical/laboratory tests and review in-depth information about each test.
CHIC2 deletion, a surrogate for FIP1L1-PDGFRA fusion, occurs in ...
WebIntroduction: The FIP1L1 / CHIC2 / PDGFRA (4q12) Deletion, Break, Triple-Color FISH probe is optimized to detect the CHIC2 deletion at 4q12 associated with the FIP1L1/PDGFRA fusion in a triple-color, split assay. It also detects translocation involving the 4q12 region. Critical region 1 (red): The CHIC2 (4q12) gene region is direct-labeled … WebFluorescence in situ hybridization (FISH) performed using the 4q12 Tri-Color Rearrangement Probe. This probe is useful for detection of chromosomal breaks that occur within PDGFRA, including translocations or interstitial deletions of 4q12 that result in the fusion of FIP1L2 with PDGFRA. These abnormalities are seen in patients with myeloid ... jay\\u0027s old electro mech seasen 4
PDGFRA (CHIC2) by FISH - Allina Health Laboratory
WebNov 1, 2003 · We used fluorescence in situ hybridization (FISH) to detect deletion of the CHIC2 locus at 4q12 as a surrogate for the FIP1L1-PDGFRA fusion. CHIC2 deletion was observed in bone marrow cells for 3 of 5 patients with SMCD associated with eosinophilia. Deletion of this locus and expression of the FIP1L1–platelet-derived growth factor … WebCHIC2 (PDGFRA 4q12) by FISH [(4q12)] Order Name: CHIC2 FISH Test Number: 9115527: Clinical Use: The PDGFRa fusion (4q12 rearrangement; interstitial deletion of CHIC2 region) is observed in diverse eosinophilia-associated hematologic disorders. Useful in predicting beneficial response to the tyrosine kinase inhibitor imatinib mesylate. WebWe used fluorescence in situ hybridization (FISH) to detect deletion of the CHIC2 locus at 4q12 as a surrogate for the FIP1L1-PDGFRA fusion. CHIC2 deletion was observed in bone marrow cells for 3 of 5 patients with SMCD associated with eosinophilia. Deletion of this locus and expression of the FIP1L1-platelet-derived growth factor receptor α ... jay\u0027s of tucson beads