Fbw7 ythdf2
WebMar 3, 2024 · Furthermore, YTHDF2 globally regulates the turnover of m6A-modified mRNAs, including the pro-apoptotic gene BMF. Conclusions Our study has … WebFBW7 counteracts the tumor-promoting effect of YTHDF2 by inducing proteasomal degradation of the latter in ovarian cancer. Furthermore, YTHDF2 globally regulates the turnover of m⁶A-modified ...
Fbw7 ythdf2
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WebDec 11, 2024 · Recently, Xu et al. identified YTHDF2 as a novel substrate for E3-ubiquitin ligase (F-box and WD repeat domain containing 7) FBW7 in OC, the latter of which is a tumour suppressor . After degradation via the proteasome system, impaired YTHDF2 impinged on mRNA decay of the proapoptotic gene bcl2 modifying factor ( BMF ) in vitro … WebFeb 19, 2024 · The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different …
WebMar 9, 2024 · In a study on ovarian cancer, FBW7 counteracted the tumorigenic effect of YTHDF2 by inducing its proteasomal degradation . In addition, researchers have demonstrated that the m 6 A reader YTHDF1 acts on EIF3C mRNA, a subunit of the protein translation initiation factor EIF3, to enhance protein translation efficiency in ovarian … WebFeb 19, 2014 · However, the role of FBW7 in the progression of ovarian cancer remains incompletely understood. ... ... Therefore, our study depicts the role of the FBW7-YTHDF2-BMF cascade in the development...
WebFBXW7 is a ubiquitin ligase that mediates ubiquitylation of oncoproteins, such as c-Myc, cyclin E, Notch, and c-Jun. FBXW7 is a known tumor-suppressor gene, and mutations in FBXW7 have been... WebFeb 10, 2024 · g In vitro YTHDF2 ubiquitination assay was performed with purified Flag-tagged WT or S263A YTHDF2, His-OGT, SCF FBW7 E3 complexes, E1, E2, Ub and …
WebApr 3, 2024 · Xu F, Li J, Ni M, Cheng J, Zhao H, Wang S, et al. FBW7 suppresses ovarian cancer development by targeting the N(6)-methyladenosine binding protein YTHDF2. …
WebOct 26, 2024 · FBW7 suppresses ovarian cancer development by targeting the N (6)-methyladenosine binding protein YTHDF2. The transcription factor IRF4 represses proapoptotic BMF and BIM to licence multiple myeloma survival. Characterization of an alternative BAK-binding site for BH3 peptides. boxing match near meWebCurrent Weather. 5:11 AM. 47° F. RealFeel® 48°. Air Quality Excellent. Wind NE 2 mph. Wind Gusts 5 mph. Clear More Details. gus hall bookWebNov 12, 2024 · This study depicted the mechanism of YTHDF2 and FBW7 in OC; FBW7 could decrease the YTHDF2-mediated m 6 A-dependent mRNA decay for stabilizing the … boxing match on saturdayWebDownload scientific diagram Regulation of m⁶A-modified mRNA stability by the FBW7-YTHDF2 cascade. a Induction of the mRNA m⁶A levels upon YTHDF2 depletion in OVCAR8and HEY cells. The RNA ... gus halper love lifeWebNational Center for Biotechnology Information boxing match nov 19WebHome - Springer boxing match nycWebFBW7 counteracts the tumor-promoting effect of YTHDF2 by inducing proteasomal degradation of the latter in ovarian cancer. Furthermore, YTHDF2 globally regulates the … boxing match result often abbr